AGEs and Aging: "tl;dnr"

Posted on 18 November 2009 by sie

I wanted to post some summarized points on AGEs to go along with my previous post. Also, now that I have had some sleep (I did that last post in the early hours of morning), I feel like this topic needs some bullet points for a quick overview understanding of the topic.

* AGEs whether consumed (exogenous) or produced inside the body (endogenous) are correlated with declining health and aging.

* Exogenous AGEs may or may not play a big role in the cross-linking that contributes to aging, but these consumed AGEs do have negative impacts on health. A study over 4 months had people eat a similar diet except one group’s food was prepared to minimize AGE content. The study found that reduced AGE consumption had surprisingly positive health benefits. (link)

* A study of CRed mice found that given the same diet with the exception of AGE content, the CRed mice with high AGE ingestion didn’t even live as long as the control group of mice. Link

* To reduce exogenous AGE consumption, avoid cooking at high temperatures (think baking and grilling), avoid long cooking times, and know that fats, meats, and processed foods have the highest AGE levels. Also, fats are even more prone to AGE production during cooking if cooked with sugar.
*  Endogenous AGE production is linked to high blood sugar and blood sugar spikes from eating high GI foods; particularly foods high in fructose and galactose.
* In a study of omnivorous and vegetarians, the omnivores actually had the lowest serum AGE levels. This is possibly because of not only higher fructose consumption in vegetarians, but taurine in meats may have protective qualities against AGEs. Link
* Link to AGE faq, and Link to exogenous AGE quantities in foods.
* Green Tea can reduce AGE formation. Link to study, and Link to a blog post on the subject.

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  1. Don’t Forget AGEs!! | immortalplan.com Says:

    [...] time readers remember, I wrote several post on the topic of AGEs (advanced glycation end products). Here is a summary post on AGEs, and here is a detailed post on a study of CR mice and AGE content in [...]

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